Diseño de un observador de la farmacocinética mediante la inversión de la farmacodinámica en anestesia general intravenosa

Juan Pablo Ramos Mendoza; Juan Onofre Orozco Lopez; Agustín Rodríguez Herrero

doi:10.17488/RMIB.46.3.1503

Authors

Juan Pablo Ramos Mendoza Master Student https://orcid.org/0009-0004-8542-5370
Juan Onofre Orozco Lopez Full time Professor Associated C
Agustín Rodríguez Herrero Full-time professor https://orcid.org/0000-0001-8400-6474

DOI:

https://doi.org/10.17488/RMIB.46.3.1503

Keywords:

BIS, NOX, Observador, General Anestesia, Pharmacokinetics-Pharmacodynamics

Abstract

In this work, the feasibility of a state-space observer applied to a cohort of virtual patients in a simulator developed in Matlab-Simulink is tested. The modeling of virtual patients can be divided into a linear part, referred to as pharmacokinetics, and a nonlinear part, corresponding to pharmacodynamics. The state-space observer is designed to estimate the state variables, or masses in the compartments associated with the pharmacokinetics of the drugs Propofol and Remifentanil. Additionally, an observer for the state variables of the pharmacokinetics of Rocuronium is integrated to make all variables available for the design and implementation of control algorithms based on state variable feedback for the coadministration of the drugs. To complete the estimation scheme for the variables comprising the mathematical modeling of the virtual patients, an approximation of the inverse functions of the nonlinear elements modeling pharmacodynamics is included; this approximation is obtained using the System Identification Toolbox. The proposed scheme and the results obtained demonstrate its feasibility and open the door to future developments in the control of anesthesia systems.

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