Más Allá de La Filogenética: Evolución Darwiniana de La Actina

Marcelo A. Moret; Gilney Zebende; James C. Phillips; Javier Quetzalcóatl Toledo Marín; Gerardo García Naumis

doi:10.17488/RMIB.40.1.6

Beyond Phylogenetics: Darwinian Evolution of Actin

Authors

Marcelo A. Moret Universidade do Estado da Bahia http://orcid.org/0000-0003-0051-6309
Gilney Zebende Universidade do Estado da Bahia
James C. Phillips Rutgers University, The State University of New Jersey
Javier Quetzalcóatl Toledo Marín Universidad Nacional Autónoma de México
Gerardo García Naumis Universidad Nacional Autónoma de México

DOI:

https://doi.org/10.17488/RMIB.40.1.6

Keywords:

proteins, Darwinian evolution, actin

Abstract

Actin polymerizes to form cytoskeletons which stabilize and direct motion of cellular walls. It is one of the most stable proteins, having evolved little from algae and yeast, and very little from fish. Here we analyze actin evolu-tion using modern theories of water-protein shaping interactions, and how these have evolved to optimize protein functions. We conclude that the failure of phylogenetic analysis to identify positive Darwinian evolution has been caused by 20th century technical limitations. These are overcome using 21st century thermodynamic scaling and modular averaging. The results for actin are especially striking, and reflect dual stable structures, globular and polymerized.

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Published

2018-12-04

How to Cite

Moret, M. A., Zebende, G., Phillips, J. C., Toledo Marín, J. Q., & García Naumis, G. (2018). Beyond Phylogenetics: Darwinian Evolution of Actin. Revista Mexicana De Ingenieria Biomedica, 40(1), 1–11. https://doi.org/10.17488/RMIB.40.1.6

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Issue

Vol. 40 No. 1 (2019): January - April

Section

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